Amiodarone May Prevent the Tilmicosin-caused Lethal Toxicity


Er A., Tras B., Cetin G., Dik B.

ACTA SCIENTIAE VETERINARIAE, cilt.42, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA SCIENTIAE VETERINARIAE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Background: Tilmicosin is widely used in veterinary medicine and its accidental overdose by injection may cause death via causing negative inotropy and positive chronotropy in both the treated animal and the veterinarian. In addition, there is no any antidote against to tilmicosin-caused death. Amiodarone blocks some channels in the heart, but it has much complex effect including vagotonic, bradycardic etc on the heart. Considering vagotonic and bradycardic effects of amiodarone, it has been hypothesised that amiodarone may prevent tilmicosin-caused death. The aim of this study was to determine the effect of amiodarone on the survival rate of rats in tilmicosin-caused lethal toxicity.