MOTTLING SCORE AND CENTRAL VENOUS OXYGEN SATURATIONIN SEPTİC SHOCK PATIENTS

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Kutluer Karaca N., Eren N., Ölmeztürk Karakurt T. C., Hayme S.

International Journal of Modern Pharmaceutical Research, cilt.7, sa.10, ss.15-20, 2023 (Hakemli Dergi)

Özet

ABSTRACT Background: Mottling score and central venous oxygen saturation are described as a clinical evaluation of microcirculation impairment having a crucial role in the physiopathology of the sepsic shock. This study describes mottling incidence and mottling score in septic shock patients according to central venous oxygen saturation. Methods: We prospectively analyzed the data of patients admitted to ICU between October 2022 to December 2022 in a tertiary teaching hospital. All septic patients in whom the ScvO2 was measured and mottling scores were evaluated were included. Data collection was realized at ICU admission (H0) and after six hours (H6); after initial resusciation. Hemodynanamic parameters, the mottling score (from 0 to 5), based on mottling area widening from the knees to the periphery and ScvO2 measured from a central intravenous catheter. Results: A total of 62 patients were included. Among patients with ScvO2 <70 at H0, SOFA score, lactate level, mean arterial pressure, and norepinephrine dose were lower than ScvO2 ≥70 (p-value <0. 001; p= 0.016; p-value <0. 001; p-value <0.001, respectively). However, there was no statistical difference in mottling in these patients. Similarly, at H6, patients with ScvO2 <, 70 had a lower SOFA score and lactate level (p-value <0.001; p-value <0.001, respectively). However, at H6, patients with ScvO2 ≥70 presented higher mottling scores than patients with ScvO2 <70 (p=0.012). Conclusion: A high level of ScvO2 in septic shock patients may be associated with higher mottling scores. However, mortality was not influenced by central venous oxygen saturation. KEYWORDS: Central oxygen saturation, microcirculation, mottling score, septic shock.