The role of proton MR spectroscopy and apparent diffusion coefficient values in the diagnosis of malignant thyroid nodules: Preliminary results

Aydin H., Kizilgöz V., Tatar I., Damar Ç., Güzel H., Hekimoǧlu B., ...Daha Fazla

Clinical Imaging, cilt.36, sa.4, ss.323-333, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.clinimag.2011.09.009
  • Dergi Adı: Clinical Imaging
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.323-333
  • Anahtar Kelimeler: Diffusion-weighted MRI, Magnetic resonance imaging, Spectroscopy, Thyroid, Thyroid cancer, Thyroid nodule
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Purpose: Performance of proton magnetic resonance spectroscopy (H-MRS) and apparent diffusion coefficient (ADC) values in the diagnosis of malignant thyroid nodules. Method: In a retrospective study with malignant nodules of 14 patients, H-MRS and diffusion-weighted MR imaging (DWI) were performed. Choline (Cho) peak, Cho/creatine (Cr) ratio, and ADC values of malignant nodules were correlated with the five benign nodules and four normal-appearing thyroid lobe parenchymata. The gold standard reference was fine needle aspiration biopsy and histopathology. Results: At echo time 40-144-ms acquisitions, average Cho/Cr ratio for the malignant nodules was 2.95±1.54-5.30±2.38, cutoff values were >0.805 and >1.225, and ADC values were 0.06±0.02. Conclusion: H-MRS acquisitions, DWI, and ADC mapping give diagnostic data about the nature of the nodules. © 2012 Elsevier Inc.