© 2021, Hacettepe University. All rights reserved.Smart formative assessment system was designed to support the problems teachers encountered in the course process. This system evaluated students’ pre-existing knowledge, their gained knowledge after the course, their learning styles and multiple intelligence types and presented suggestions to the teachers for the course process in regard to the expert system method, one of artificial intelligence methods. The aim of this study was to examine the effects of a smart formative assessment system on students' academic achievement levels and course process. Through sequential explanatory design of mixed research methods, two biology teachers and 122 grade 10 students participated in the study. The results indicated that the smart formative assessment system increased the students’ academic success levels. In addition, it was found that the smart formative assessment system not only drove the teachers to use individualized methods in their course process, but also facilitated the implementation of formative assessment in their courses. As a result, some suggestions are made for testing smart formative assessment systems to teach different topic(s), courses and possible smart formative assessment systems that will be prepared for formative assessment.