THE RELATIONSHIP BETWEEN FASTING BLOOD GLUCOSE LEVEL AND INTRAERYTHROCYTE ANTIOXIDANT AND SELENIUM LEVELS IN TYPE I AND TYPE II DIABETICS
32. Ulusal Biyokimya Kongresi, Gaziantep, Turkey, 27 - 31 October 2021, pp.61, (Summary Text)
- Publication Type: Conference Paper / Summary Text
- City: Gaziantep
- Country: Turkey
- Page Numbers: pp.61
- Erzincan Binali Yildirim University Affiliated: No
Abstract
BACKGROUND AND AIM: Diabetes Mellitus (DM) is a metabolic disease
characterized by insulin deficiency or insulin ineffectiveness resulting from
impaired insulin synthesis. Constantly high blood glucose levels cause the
formation of free radicals. The aim of this study is to examine the relationships
between DM and blood glucose, antioxidants and selenium levels.
METHODS: In patients with Type I (n=30) and Type II (n=70) Diabetes Mellitus,
blood glucose levels, SOD, CAT, GSH-Px activities were determined by
spectrophotometric measurement. Selenium (Se) level was measured in serum by
ICP-MS device and the results were compared with control groups (n=20, n=30).
RESULTS: In patients with type I DM (n=30), blood glucose levels and GSHPx were found to be significantly higher when compared to the control group
(p< 0.05). No statistically significant difference was found in SOD, CAT and Se
levels. When compared with the control group, patients with type II DM (n=70)
had significantly higher blood glucose levels and significantly lower SOD, CAT,
GSH-Px and Se values (p< 0.05).
CONCLUSIONS: Hem Tip I DM’de hem de Tip II DM’de artan glukoz
seviyesinin, serbest radikallerin meydana gelme mekanizmalarini aktive ettigi
ve serbest radikallerin ortadan kaldirilmasini saglayan antioksidan savunma
sisteminin aktivasyonuna neden olabilecegi kanisini ortaya koymaktadir.
Keywords: Antioxidants, Diabetes Mellitus, Oxidative stress, Free radicals,Selenium