Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal inflammatory drug


Suleyman H., ÇADIRCI E., ALBAYRAK A., HALICI Z.

Current Medicinal Chemistry, vol.15, no.3, pp.278-283, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 15 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.2174/092986708783497247
  • Journal Name: Current Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.278-283
  • Keywords: Antiulcer effect, Chemical structure, Cyclooxygenase, Nimesulide, NSAID, Side effect
  • Erzincan Binali Yildirim University Affiliated: No

Abstract

In this review it is shown that nimesulide, a selective cyclooxigenase-2 (COX-2) inhibitor, is different from other selective COX-2 inhibitors and classical non-steroidal anti-inflammatory drugs (NSAIDs). The anti-inflammatory effect mechanism of nimesulide (inhibition of inflammatory mediators) is similar to other classic NSAIDs, but the protective effect of nimesulide on classic NSAID-induced ulcers elucidates the difference between nimesulide and these other drugs. It is known that the selective COX-2 inhibitor nimesulide prevents NSAID-induced ulcers, while celecoxib and rofecoxib, which are more selective to COX-2, failed to prevent these ulcers. Nimesulide produces gastro-protective effects via a completely different mechanism. In addition, while selective COX-2 inhibitors increase the risk for cardiovascular diseases, nimesulide does not exert significant cardiotoxicity. This data suggests that gastrointestinal side effects of classic NSAIDs cannot be related to the COX-1 inhibition alone and also suggest that nimesulide is an atypical NSAID, which is different from both non-selective and selective COX-2 inhibitors. © 2008 Bentham Science Publishers Ltd.