Association Between Atherogenic Index of Plasma, Blood Pressure and Impaired Glucose Metabolism; Results of Diabetes Screening in a Tertiary Healthcare Center


AKBAŞ E. M. , AKBAŞ N., TİMUROĞLU A., DEMİRTAŞ L., ÖZÇİÇEK F., ÖZÇİÇEK A.

Archives of Basic and Clinical Research, vol.2, 2020 (Peer-Reviewed Journal)

Abstract

Objective: Atherogenic index of plasma (AIP) is a relatively new index used to predict the risk of cardiovascular diseases in the general population. AIP has been shown to be associated with increased fasting plasma glucose (FPG) levels, diabetes mellitus, and metabolic syndrome. However, to the best of our knowledge, no study has investigated the relationship between AIP and impaired glucose metabolism using oral glucose tolerance test and hemoglobin A1c (HbA1c) level. Materials and Method: AIP was calculated using the formula involving the logarithm of the molar ratio of triglyceride to high-density lipoprotein cholesterol. The association among AIP, glucose metabolism parameters, and diabetes status was analyzed. Results: The frequency of prediabetes and diabetes among the study subjects was 48.2% (n=216) and 20.5% (n=92), respectively. Overall, 52.7% of the subjects were in the low-risk group (AIP<0.11), 12.5% in the intermediate-risk group (AIP 0.11–0.21), and 34.8% in the high-risk group (AIP>0.21). An increased AIP (high-risk group) was significantly associated with prediabetes and diabetes. AIP was also significantly correlated with systolic and diastolic blood pressures and HbA1c, FPG, and 2-hour plasma glucose levels. Conclusions: AIP was significantly associated with the parameters of diabetes and metabolic syndrome. Simple calculations from fasting lipid panel results may provide further information to evaluate the risk of cardiovascular diseases risk in patients with prediabetes and diabetes.