Effects of different doses of dexamethasone plus flunixin meglumine on survival rate in lethal endotoxemia
Acta Veterinaria, cilt.59, sa.1, ss.47-51, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 1
- Basım Tarihi: 2009
- Doi Numarası: 10.2298/avb0901047e
- Dergi Adı: Acta Veterinaria
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.47-51
- Anahtar Kelimeler: Dexamethasone, Flunixin, Lethal endotoxaemia, Survival rate
- Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır
Özet
Effects of different closes of dexamethasone plus flunixin meglumine on survival rate were investigated in lethal endotoxemia. A total of 60 Balb/C female mice were divided into 4 equal groups. Lethal endotoxemia (80-100%) was induced by lipopolysaccharide injection (Group 1, 1 mg, intraperinoneally). At 4 hours after the lipopolysaccharide injection; low-dose dexamethasone (0.6 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously), normal-dose dexamethasone (2 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) and high-dose dexamethasone (10 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) were injected to Group 2, 3 and 4, respectively. After the injections, survival was monitored at 7 days and 13.3%, 13.3%, 33.3% and 73.3% survival rates were observed in Groups 1, 2, 3 and 4, respectively. As results, high-dose dexamethasone plus flunixin meglumine may be the treatment of choice for endotoxaemia in animals.