Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

Colluoglu C., Balci S., GÜNDOĞDU B., ÇOBAN T. A., Bulut S., SÜLEYMAN H.

Bangladesh Journal of Pharmacology, cilt.17, sa.3, ss.72-78, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3329/bjp.v17i3.59418
  • Dergi Adı: Bangladesh Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.72-78
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclo-phosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone atte-nuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.