The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

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Acun Delen L., Korkmaz Dişli Z., Taş H. G., Kuyrukluyildiz U., Yazici G. N., Süleyman B., ...Daha Fazla

General physiology and biophysics, cilt.41, sa.1, ss.63-70, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4149/gpb_2021043
  • Dergi Adı: General physiology and biophysics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.63-70
  • Anahtar Kelimeler: Antioxidants, Liver, Oxidative stress, Propofol, Thiamine pyrophosphate
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Propofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofolinduced liver damage.