Isolation of Undescribed Biflavonoid from Potamogeton pusillus L. and Antidiabetic Activity Properties

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AKŞİT H.

Records of Natural Products, cilt.17, sa.3, ss.501-508, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.25135/rnp.385.2211.2628
  • Dergi Adı: Records of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.501-508
  • Anahtar Kelimeler: antidiabetic properties, biflavonoid, Potamogeton pusillus L, sulfated flavones, α-glucosidase
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

A phytochemical study on the Potamogeton pusillus L. led to the isolation and identification of a novel biflavonoid, pusillin A (1) with known seven compounds, including rosmarinic acid (2), luteolin-7-sulfate (3), eriodictyol-7-sulfate (4), chrysoeriol-7-sulfate (5), eriodictyol (5), luteolin (7) and chrysoeriol (8). Their structures were elucidated based on spectrometric analysis, including LC-Q-TOF/MS and NMR. All compounds were screened for in vitro antidiabetic activity using the spectrophotometric method. Sulfated flavones (1, 3, 4, and 5) exhibited prominent α-glucosidase inhibitory activity, and compounds 2, 6, 7, and 8 showed moderate inhibitory activities. All isolates were reported for the first time from the plant material.