Akademik Veri Yönetim Sistemi
Archives of Medical Science - Civilization Diseases, cilt.6, ss.103-108, 2021 (Hakemli Dergi)
Introduction: The aim of this study is to examine the oxidative damage
caused by sunitinib on skeletal muscle and whether taxifolin is effective
against that oxidative damage.
Material and methods: Thirty albino Wistar male rats were used in the experiment. The rats were divided into 3 equal-sized groups: a sunitinib-only
administered group (SUN), a sunitinib + taxifolin administered group (SUT),
and a control group (CG) without treatment. Taxifolin and sunitinib were
administered by oral gavage at a dose of 50 mg/kg for taxifolin and a dose
of 25 mg/kg for sunitinib. Striated hind limb muscle tissue of rats was removed; malondialdehyde (MDA), reduced glutathione (GSH), and superoxide
dismutase (SOD) levels were measured in muscle tissue; muscle tissue was
examined histopathologically; creatine kinase (CK) levels were determined
in the blood samples of rats; and the results were compared between the
groups.
Results: In the SUN group, MDA and CK values were statistically significantly
higher than in the SUT and CG groups, but SOD and GSH values were statistically significantly lower. The SUT and CG groups were similar when compared. Histopathologically, congested blood vessels, oedema, degeneration,
inflammation, and rupture of muscle fibres in muscle tissue were detected
in the SUN group. However, in the SUT group it was observed that blood
vessels were normal, there were no degenerative findings, and inflammation
was resolved.
Conclusions: Sunitinib causes oxidative damage to skeletal muscle tissue.
Taxifolin prevents the toxic effect of sunitinib on skeletal muscle due to its
antioxidant effects.
Key words: skeletal muscle, sunitinib, oxidative damage, taxifolin.