Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis

Huyut Z., BAKAN N., YILDIRIM S., Alp H. H.

MEDICAL SCIENCE MONITOR BASIC RESEARCH, vol.24, pp.47-58, 2018 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2018
  • Doi Number: 10.12659/msmbr.908504
  • Journal Name: MEDICAL SCIENCE MONITOR BASIC RESEARCH
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.47-58
  • Keywords: Bone Density, Dexamethasone, Osteoporosis, Phosphodiesterase 5 Inhibitors, NITRIC-OXIDE, MINERAL DENSITY, ANTIOXIDANT ACTIVITY, COENZYME Q(10), DNA-DAMAGE, STRESS, OVARIECTOMY, EXPRESSION, SUSCEPTIBILITY, METABOLISM
  • Erzincan Binali Yildirim University Affiliated: No

Abstract

Background: The aim of this study was to evaluate the effects of the phosphodiesterase-5 (PDE-5) inhibitors, zaprinast and avanafil, on NO signalling pathway, bone mineral density (BMD), epiphyseal bone width, bone marrow angiogenesis, and parameters of oxidative stress in a rat model of glucocorticoid-induced osteoporosis (GIOP).