Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat

Atila Uslu G., Uslu H.

Archives of Physiology and Biochemistry, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2019
  • Doi Number: 10.1080/13813455.2019.1668018
  • Journal Name: Archives of Physiology and Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Adiponectin, Fibronectin type III domain-containing protein 5, Juglans regia, Type 2 diabetes
  • Erzincan Binali Yildirim University Affiliated: No


© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group (p <.01, p <.001 respectively). In the D + JR group, there was a significant increase in plasma FNDC5 and ADP (p <.05), while the plasma Tumour necrosis factor-alpha (TNF-α) levels were decreased compared to the DC group (p <.001). Conclusions: In conclusion, the present study found that JR and its bioactive components alleviated insulin resistance by increasing ADP and FNDC5 and decreasing FBG in a rat model of streptozotocin (STZ) + nicotinamide (NAD)-induced type 2 diabetes (T2D).HighlightsJuglans regia extract increased insulin sensitivity. Juglans regia extract significantly reduced the level of fasting blood glucose. Juglans regia extract reduced TNF-α levels in rats with type 2 diabetes. Juglans regia extract prevent weight loss in type 2 diabetes.