Akademik Veri Yönetim Sistemi
3rd EURASIA BIOCHEMICAL APPROACHES & TECHNOLOGIES (EBAT) CONGRESS SCIENTIFIC PROGRAMME, Antalya, Türkiye, 4 - 07 Kasım 2021, ss.167
Diabetes mellitus (DM) is a disease whose prevalence is increasing every year in the world, threatening
human health, and causing serious and permanent damage to the organs of the living thing if left
untreated. Although anti-diabetic drugs have been used for a long time in the treatment of this disease,
an effective result has not been reached yet. Therefore, there is a need for drugs that are more
effective and have the power to maintain their effect for a long time in the treatment of DM.
1
Plant species that are considered safe plants have been widely used in traditional treatment due to
their anti-hyperglycemia, anti-inflammation and anti-oxidation properties. Species belonging to the
genus Berberis have been used in the treatment of diabetes. In the literature, it is reported that the
berberine substance found in Berberis species has a regulatory effect on glucose metabolism.2 It is
emphasized that berberine has effects of promoting intestinal glucagon-like protein-1 secretion,
increasing mRNA expression of hepatic low-density lipoprotein receptor and increasing the level of
glucose transporter.3
It was aimed to investigate the effects of water extracts of barberry plant root, systematically named
Berberis crataegina DC, on rats with alloxan-induced diabetes. In the blood plasma of alloxan-induced
diabetic rats of these extracts; the effects on the levels of glucose, insulin, HbA1c, aspartate amino
transferase, alanine amino transferase and alkaline phosphatase enzymes were investigated. For this,
water extracts obtained from the plant root were applied to the rats. In our study, 36 Albino Wistar
male rats were used. Rats were divided into 6 groups, 6 in each group: 1. Control group, 2. Diabetesinduced control group, 3. Healthy and B. crataegina extract applied group, 4th, 5th and 6th groups
were diabetes-induced and B. crataegina in different doses. Extracts were determined as applied. B.
crataegina extracts were given orally to the 3rd, 4th, 5th and 6th groups for 15 days. On the 5th, 10th
and 15th days, glucose measurements were made in the blood taken from the tail of the rats.
Afterwards, the animals were euthanized and biochemical and histopathological examinations were
performed on blood samples and tissue samples.