Detection of insulin-like growth factor receptor-1 in the human cremaster muscle and its role in the etiology of the undescended testis


ÖZDAMAR M. Y., Sahin S., Zengin K., SEÇKİN S., GURDAL M.

ASIAN JOURNAL OF SURGERY, cilt.42, sa.1, ss.290-296, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.asjsur.2018.02.005
  • Dergi Adı: ASIAN JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.290-296
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Purpose: Previous studies of undescended testis (UT) has focused on insulin-like hormone 3 (INSL3), the genitofemoral nerve, and androgens in the testicular descent. Leydig cells, which are under the control of insulin-like growth factor-1 (IGF1), produce both androgens and INSL3. We aimed to investigate whether insulin-like growth factor receptor-1(IGFR1) exists in the cremaster muscle (CM) complex and is associated with normally descended testis as well as UT cases in humans.