Determination of Solifenacin Succinate in Human Plasma and Pharmaceutical Formulations Using HPLC-UV
Bioorganic & Medicinal Chemistry Reports, cilt.2, sa.1, ss.15-23, 2019 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.25135/bmcr.17.19.10.1451
- Dergi Adı: Bioorganic & Medicinal Chemistry Reports
- Derginin Tarandığı İndeksler: Other Indexes
- Sayfa Sayıları: ss.15-23
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Erzincan Binali Yıldırım Üniversitesi Adresli: Evet
Özet
An accurate, rapid and precise high performance liquid chromatographic coupled with ultraviolet detector method has been developed for the determination of solifenacin succinate in pharmaceutical formulation and human plasma. Quantitative analysis of solifenacin succinate was performed using a C18 column at wavelength at 210 nm. The mobile phase consisted of 10 mM ammonium formate buffer (pH 4.0), acetonitrile and methanol (52.5:32.5:12.5 v/v/v). The method showed linearity in the concentration range of 3-60 μg/mL and the correlation coefficient was 0.9998 and 0.9994 for the standard and human plasma solutions, respectively. The proposed method was within acceptable limits in terms of accuracy, precision, selectivity, linearity, sensitivity and recovery parameters. This method is readily applicable for the determination of solifenacin succinate in human plasma and pharmaceutical formulations.