Four diclofenac complexes with cobalt(II) and nickel(II) ions: synthesis, spectroscopic properties, thermal decompositions, crystal structures, and carbonic anhydrase activities

ÇAĞLAR S. , AYDEMIR I. E. , ÇANKAYA M. , KUZUCU M. , Temel E., Buyukgungor O.

JOURNAL OF COORDINATION CHEMISTRY, cilt.67, ss.969-985, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 67 Konu: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/00958972.2014.903327
  • Sayfa Sayıları: ss.969-985


Cobalt(II) and nickel(II) complexes with diclofenac (dicl) in the presence of nitrogen-donor 3-picoline (3-pic) and 1-(2-aminoethyl)pyrrolidine (2-aepyr), [Co(dicl)(2)(3-pic)(2)] (1), [Ni(dicl)(2)(3-pic)(2)(H2O)(2)] (2), [Co(dicl)(2)(2-aepyr)(2)] (3), and [Ni(dicl)(2)(2-aepyr)(2)] (4), have been synthesized and characterized by FT-IR, UV-Vis, elemental and thermal analysis. The crystal structures of 1 and 3 have been determined by single-crystal X-ray diffraction; phase purity of complexes has been proved by powder X-ray diffraction analysis. Structural analyses have demonstrated that 1 and 3 are mononuclear and Co(II) ions have distorted octahedral environments. In 1, dicl is bidentate, whereas in 2, 3, and 4 dicl is monodentate. Dicl ligands are coordinated to metal(II) ions with O of carboxylate. Therefore, IR spectra of all complexes display {nu(OCO)(asym) and nu(OCO)(sym)} of dicl. The calculated Delta nu(OCO) values are consistent with the presence of monodentate (>200) and bidentate (<200) carboxylate. Compounds 2, 3, and 4 exhibit inhibition effects on human carbonic anhydrase-I. Compounds 3 and 4 show high thermal stability compared with 1 and 2.