The Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Rats

Disli Z. K., Acun Delen L., Tas H. G., KUYRUKLUYILDIZ U., DİŞLİ O. M., YAZICI G. N., ...Daha Fazla

Latin American Journal of Pharmacy, cilt.41, sa.1, ss.130-137, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 1
  • Basım Tarihi: 2022
  • Dergi Adı: Latin American Journal of Pharmacy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.130-137
  • Anahtar Kelimeler: antioxidant, carvacrol, desflurane, hepatotoxicity, inhalation anesthesia
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

© 2022, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.The metabolite of desflurane has been linked to hepatotoxicity. Carvacrol possesses antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, and spasmolytic properties, according to research. Our goal is to demonstrate that carvacrol protects rats’ livers against repeated doses of desflurane. Healthy (HG), desflurane (DS), and carvacrol + desflurane treatment (CDS) groups were formed from 18 albino male Wistar rats. A single dosage of carvacrol and 6% desflurane was given for 2 h on the 0th and 8th days. In the CDS group, the ALT and AST, MDA, TOS, NF-xB, TNF-α IL1 β levels were lower compared to the DS group (p < 0.001). The tGSH,TAS levels were found to be higher in the CDS group compared to the DS group (p < 0.001). It was determined that the mean degeneration level, Kupffer cell activation and PMNL infiltration were found to be lower compared to the DS group (p < 0.05).We confirmed that carvacol can be used in the treatment of desflurane-related liver injury.