The effect of rutin on cisplatin-induced oxidative cardiac damage in rats.

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Topal İ., Bilgin A. O., Cimen F., Kurt N., SÜLEYMAN Z., BİLGİN Y., ...Daha Fazla

Anatolian journal of cardiology, cilt.20, sa.3, ss.136-142, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14744/anatoljcardiol.2018.32708
  • Dergi Adı: Anatolian journal of cardiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.136-142
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Objective: Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the effect of rutin on cisplatin-induced cardiotoxicity in rats.