Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats
Asian Pacific Journal of Reproduction, cilt.10, sa.4, ss.168-175, 2021 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.4103/2305-0500.321124
- Dergi Adı: Asian Pacific Journal of Reproduction
- Derginin Tarandığı İndeksler: Scopus, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.168-175
- Anahtar Kelimeler: Antioxidants, Ischemia-reperfusion, Ovarian damage, Ovarian torsion, Oxidative stress, Rat, Taxifolin
- Erzincan Binali Yıldırım Üniversitesi Adresli: Evet
Özet
© 2021 Asian Pacific Journal of Reproduction Produced by Wolters Kluwer- Medknow. All rights reservedObjective: To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats. Methods: A total of 18 female Wistar albino rats were randomly and equally divided into three groups: the sham group, the ovarian ischemia reperfusion group, and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group. The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol. Biochemical and histopathologic examinations were performed on the extracted ovaries. Results: Levels of malondialdehyde and cyclooxygenase-2 were increased, while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group. However, these values were reversed in the taxifolin+ovarian ischemia reperfusion group. Similarly, the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group, while they were within normal range in the taxifolin+ovarian ischemia reperfusion group. Conclusions: Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury, and taxifolin may be useful for protecting ovarian tissue from such injury.