The effects of newly synthesized pyrazole derivatives on formaldehyde-carrageenan-, and dextran-induced acute paw edema in rats

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Süleyman H., Büyükokuroǧlu M.

Biological and Pharmaceutical Bulletin, cilt.24, sa.10, ss.1133-1136, 2001 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 10
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1248/bpb.24.1133
  • Dergi Adı: Biological and Pharmaceutical Bulletin
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1133-1136
  • Anahtar Kelimeler: New pyrazole derivative, Paw edema, Rat
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

The antiinflammatory effects of 10 newly synthesized pyrazole derivatives on formaldehyde-induced rat paw edema were investigated. The most effective of them (K-3) was investigated again in dextran- and carrageenan-induced paw edema. In formaldehyde-induced paw edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the edema by 48.9% (p<0.002), 68.7% (p<0.001), and 79.1% (p<0.001), respectively, 3 h after administration. In dextran-induced paw edema, the same dose of K-3 produced 27.1% (p<0.05), 46.8% (p<0.01), and 63.8% (p<0.002) inhibition, respectively. In the carrageenan-induced paw edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4 h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg.