Preventive Effect of Intrathecal Paracetamol on Spinal Cord Injury in Rats

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Sahin M., SAYAR İ., Peker K., GÜLLÜ H., Yildiz H.

IRANIAN RED CRESCENT MEDICAL JOURNAL, cilt.16, sa.11, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5812/ircmj.22151
  • Dergi Adı: IRANIAN RED CRESCENT MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Background: Ischemic injury of the spinal cord during the surgical repair of thoracoabdominal aortic aneurysms might lead to paraplegia. Although a number of different mechanisms have been proposed, the exact cause of paraplegia has remained unknown, hampering the development of effective pharmacologic or other strategies for prevention of this condition. A number of studies suggested that cyclooxygenases (COX) contribute to neural breakdown; thus, COX inhibitors might reduce injury.