Preventive Effect of Intrathecal Paracetamol on Spinal Cord Injury in Rats
IRANIAN RED CRESCENT MEDICAL JOURNAL, cilt.16, sa.11, 2014 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 11
- Basım Tarihi: 2014
- Doi Numarası: 10.5812/ircmj.22151
- Dergi Adı: IRANIAN RED CRESCENT MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Erzincan Binali Yıldırım Üniversitesi Adresli: Evet
Özet
Background: Ischemic injury of the spinal cord during the surgical repair of thoracoabdominal aortic aneurysms might lead to paraplegia. Although a number of different mechanisms have been proposed, the exact cause of paraplegia has remained unknown, hampering the development of effective pharmacologic or other strategies for prevention of this condition. A number of studies suggested that cyclooxygenases (COX) contribute to neural breakdown; thus, COX inhibitors might reduce injury.