Zaprinast and avanafil increase the vascular endothelial growth factor, vitamin D-3, bone morphogenic proteins 4 and 7 levels in the kidney tissue of male rats applied the glucocorticoid
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.128, sa.5, ss.1290-1296, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 128 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/13813455.2020.1767149
- Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1290-1296
- Anahtar Kelimeler: Angiogenesis, phosphodiesterase-5 inhibitor, dexamethasone, bone morphogenetic protein, vitamin D3, 1,25-DIHYDROXYVITAMIN D-3, PHOSPHODIESTERASE-5 INHIBITOR, OXIDATIVE DAMAGE, VEGF, EXPRESSION, DIFFERENTIATION, ACCUMULATION, MODEL, BMP-2
- Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır
Özet
Objective: This study investigated effect of zaprinast and avanafil on vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 4 and 7, and vitamin D-3 levels against the negative effect of dexamethazone. Method: Rats were randomly divided into four groups (n = 6). Control: Empty a syringe was immersed and removed subcutaneously. Dexamethasone (DEX): 120 mu g/kg DEX was injected subcutaneously once a day for 28 days. DEX + zaprinast and DEX + avanafil groups: 10 mg/kg zaprinast and avanafil were administrated to rats in addition to the same procedure in the DEX, respectively. VitaminD(3), VEGF, BMP4 and 7 levels by enzyme linked immunosorbent assay (ELISA) and angiogenesis by histopathological/immunohistochemical were evaluated. Results: BMP4 values in the DEX were lower than the other groups (p < .05). DEX + zaprinast and DEX + avanafil exhibited an increase in all the parameters compared to the control and DEX (p < .05). However, these were not significant for the DEX + zaprinast (p > .05). Also, there was a significant increase in angiogenesis in the DEX + zaprinast and DEX + avanafil. Conclusion: Zaprinast and significantly avanafil induced vitamin D-3, BMP4 and 7 levels by increasing angiogenesis in renal.