Zaprinast and avanafil increase the vascular endothelial growth factor, vitamin D-3, bone morphogenic proteins 4 and 7 levels in the kidney tissue of male rats applied the glucocorticoid


Huyut Z., BAKAN N., Akbay H. İ., YILDIRIM S., ŞEKEROĞLU M. R.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.128, no.5, pp.1290-1296, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1080/13813455.2020.1767149
  • Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1290-1296
  • Keywords: Angiogenesis, phosphodiesterase-5 inhibitor, dexamethasone, bone morphogenetic protein, vitamin D3, 1,25-DIHYDROXYVITAMIN D-3, PHOSPHODIESTERASE-5 INHIBITOR, OXIDATIVE DAMAGE, VEGF, EXPRESSION, DIFFERENTIATION, ACCUMULATION, MODEL, BMP-2
  • Erzincan Binali Yildirim University Affiliated: No

Abstract

Objective: This study investigated effect of zaprinast and avanafil on vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 4 and 7, and vitamin D-3 levels against the negative effect of dexamethazone. Method: Rats were randomly divided into four groups (n = 6). Control: Empty a syringe was immersed and removed subcutaneously. Dexamethasone (DEX): 120 mu g/kg DEX was injected subcutaneously once a day for 28 days. DEX + zaprinast and DEX + avanafil groups: 10 mg/kg zaprinast and avanafil were administrated to rats in addition to the same procedure in the DEX, respectively. VitaminD(3), VEGF, BMP4 and 7 levels by enzyme linked immunosorbent assay (ELISA) and angiogenesis by histopathological/immunohistochemical were evaluated. Results: BMP4 values in the DEX were lower than the other groups (p < .05). DEX + zaprinast and DEX + avanafil exhibited an increase in all the parameters compared to the control and DEX (p < .05). However, these were not significant for the DEX + zaprinast (p > .05). Also, there was a significant increase in angiogenesis in the DEX + zaprinast and DEX + avanafil. Conclusion: Zaprinast and significantly avanafil induced vitamin D-3, BMP4 and 7 levels by increasing angiogenesis in renal.