Investigation of the Cytotoxic Effect of Different Extracts of Lallemantia Canescens (L) Fisch & Fruit Plant on Cancer Cell Lines

Alp C., Altın S., Köksal E., Altay A.

3rd Eurasia Biochemical Approaches & Technologies (EBAT), Antalya, Turkey, 4 - 07 November 2021, pp.112

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.112
  • Erzincan Binali Yildirim University Affiliated: Yes


Plants have been used as medicine since ancient times, as they reorganize the body balance and increase the resistance of the patient against the damage caused by cancer in the tissues.1 It has been determined that these properties of medicinal plants are due to the bioactive compounds in their structures.1,2 Medicinal plants are a very important resource in cancer treatment because they are easily and cheaply available compared to modern drugs and do not show toxic effects.3 The Lamiaceae family is among the largest families in the world, with approximately 236 genera and 7173 taxa, especially grown in temperate regions. In our country, Lamiaceae family ranks fourth with 586 species and ranks third among endemics.4 Some members of the Lamiaceae family continue to be used in folk medicine in various parts of the world.5 Although there are biological activity studies for various species of the Lamiaceae family, no studies have been found on the phytochemical content and anticancer studies of Lallemantia canescens. In this study, the cytotoxic effects of various extracts (hexane, ethyl acetate, methanol and water) from the aerial parts of Lallemantia canescens were investigated. The cytotoxicity of the extracts was investigated by XTT assay on human colorectal adenocarcinoma (HT29), human lung adenocarcinoma (A549) and human breast adenocarcinoma (MCF-7) cells. According to XTT assay results, while methanol was the extract with the highest cytotoxicity in A549 cell line, water and ethyl acetate extracts showed the highest cytotoxic effect among all extracts for MCF-7 and HT-29.