Cobalt oxide nanoparticles as a promising antifungal agent for Candida species: Eco-friendly synthesis from Platanus orientalis L. leaf extract and its applications
Journal of Industrial and Engineering Chemistry, cilt.154, ss.791-805, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 154
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jiec.2025.07.043
- Dergi Adı: Journal of Industrial and Engineering Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
- Sayfa Sayıları: ss.791-805
- Anahtar Kelimeler: Antifungal effect, Candida species, Cytotoxicity, Green synthesis, Magnetic nanoparticles, Platanus orientalis L. extract
- Erzincan Binali Yıldırım Üniversitesi Adresli: Evet
Özet
The development of environmentally compatible nanomaterials with biomedical potential has garnered increasing interest. In this study, cobalt oxide nanoparticles (Co3O4-NPs) were synthesized by an eco-friendly method using Platanus orientalis L. leaf extract as a reducing and stabilizing agent. Structural and physicochemical characterizations confirmed the successful formation of spinel-type Co3O4-NPs with controlled size and morphology. Synthesis at pH 12 resulted in smaller (22.70 nm) and more stable nanoparticles which showed increased anticandidal activity. The minimum inhibitory concentrations (MIC: 3.91, 7.81, and 1.95 mg/mL) and the minimum fungicidal concentrations (MFC: 15.63, 62.50, and 7.81 mg/mL) indicated a strong antifungal effect against Candida albicans, Candida tropicalis, and Candida glabrata, respectively. In addition, Co3O4-NPs showed concentration-dependent cytotoxicity on MDA-MB-231 breast cancer cells with the inhibition concentration 50 value (IC50: 0.07 mg/mL 24-h) indicating potential anticancer effect. These results highlight the dual antifungal and cytotoxic capabilities of biogenically synthesized Co3O4-NPs, making them strong candidates for future biomedical applications.