Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation

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Cerrah S., Akbas N., ÖZÇİÇEK F., MAMMADOV R., ALTUNER D., SÜLEYMAN H., ...Daha Fazla

Experimental Animals, cilt.72, sa.4, ss.513-519, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1538/expanim.22-0065
  • Dergi Adı: Experimental Animals
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.513-519
  • Anahtar Kelimeler: aspirin, biochemical, gastric damage, rat, taxifolin
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.