Activation of Two Different Drugs Used in Alzheimer's Disease Treatment on Human Carbonic Anhydrase Isozymes I and II Activity: an In Vitro Study

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DİLEK E.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.2, pp.164-168, 2017 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.43434
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.164-168
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Objectives: Human carbonic anhydrase I and II (hCAI, II) isoenzymes were purified from human erythrocyte. Kinetic interactions between the enzymes and memantine and donepezil, two different drugs used in Alzheimer's disease (AD) treatment, were investigated.