EFFECT OF LUTEIN ON OXIDANTS AND PROINFLAMMATORY CYTOKINE-RELATED LIVER ISCHEMIA-REPERFUSION INJURY

Creative Commons License

GÜNDOĞDU B., Taş H. G., SÜLEYMAN B., Mamedov R., YÜCE N., KUYRUKLUYILDIZ U., ...More

Acta Poloniae Pharmaceutica - Drug Research, vol.79, no.1, pp.129-135, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.32383/appdr/147645
  • Journal Name: Acta Poloniae Pharmaceutica - Drug Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, International Pharmaceutical Abstracts
  • Page Numbers: pp.129-135
  • Keywords: oxidative stress, lutein, liver, ischemia, reperfusion
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

© 2022 Polish Pharmaceutical Society. All rights reserved.Lutein has an anti-inflammatory impact on tissues, according to recent research. The goal of our research was to see how lutein affected the biochemical and histological results of ischemia-reperfusion (I/R) intervention on rats' livers. A total of 18 rats were divided into a sham operation group (HG), a liver I/R (KIR) group, or lutein (1mg/kg)+liver I/R (LIR) groups. Biochemical measures and histological exams were done in all three groups after I/R intervention. MDA, NF-κB, TNF-α, IL-1, ALT, and AST levels were significantly higher (p < 0.001) in the KIR group compared to the HG and LIR groups, although tGSH was significantly lower (p < 0.001). The HG group was histopathologically normal. The KIR group had severe degeneration, necrosis, and inflammation in the portal area and parenchyma. The LIR group had mild inflammation in the portal area and parenchyma. The use of lutein might be an alternative treatment for liver damage caused by I/R responses during surgery.