EFFECT OF LUTEIN ON OXIDANTS AND PROINFLAMMATORY CYTOKINE-RELATED LIVER ISCHEMIA-REPERFUSION INJURY

Creative Commons License

GÜNDOĞDU B., Taş H. G., SÜLEYMAN B., Mamedov R., YÜCE N., KUYRUKLUYILDIZ U., ...Daha Fazla

Acta Poloniae Pharmaceutica - Drug Research, cilt.79, sa.1, ss.129-135, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.32383/appdr/147645
  • Dergi Adı: Acta Poloniae Pharmaceutica - Drug Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.129-135
  • Anahtar Kelimeler: oxidative stress, lutein, liver, ischemia, reperfusion
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

© 2022 Polish Pharmaceutical Society. All rights reserved.Lutein has an anti-inflammatory impact on tissues, according to recent research. The goal of our research was to see how lutein affected the biochemical and histological results of ischemia-reperfusion (I/R) intervention on rats' livers. A total of 18 rats were divided into a sham operation group (HG), a liver I/R (KIR) group, or lutein (1mg/kg)+liver I/R (LIR) groups. Biochemical measures and histological exams were done in all three groups after I/R intervention. MDA, NF-κB, TNF-α, IL-1, ALT, and AST levels were significantly higher (p < 0.001) in the KIR group compared to the HG and LIR groups, although tGSH was significantly lower (p < 0.001). The HG group was histopathologically normal. The KIR group had severe degeneration, necrosis, and inflammation in the portal area and parenchyma. The LIR group had mild inflammation in the portal area and parenchyma. The use of lutein might be an alternative treatment for liver damage caused by I/R responses during surgery.