Effect of Rutin on Gentamicin-Induced Ototoxicity in Rats: A Biochemical and Histopathological Examination

Salcan İ., Dilber M., Bayram R., Suleyman E., Yazıcı G. N., Coban A., ...More

ENT UPDATES, vol.11, no.1, pp.8-13, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.5152/entupdates.2021.887158
  • Journal Name: ENT UPDATES
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.8-13
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Objective: Gentamicin is a broad-spectrum aminoglycoside antibiotic administered parenterally for moderate to severe gram-negative infections. Ototoxicity is an important side effect that limits gentamicin use. The aim of this study is to investigate the effect of rutin on gentamicin-induced ototoxicity in rats biochemically and histopathologically.