The Determination of the Genotoxic Effects of Genistein that an Environmental Pollutant on Drosophila Melanogaster


AŞKIN H., UYSAL H., Altun D., Ayar A.

EKOLOJI, vol.19, no.75, pp.82-87, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 75
  • Publication Date: 2010
  • Doi Number: 10.5053/ekoloji.2010.7511
  • Journal Name: EKOLOJI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.82-87
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Genistein is a phytoestrogen that aquatic environment contaminant and is found in a wide variety of plant-derived foods especially in soybeans and soy-based foods. In this study, the potential genotoxic effects of genistein which available from several factories waste were researched via using Drosophila wing somatic mutation and recombination test (SMART). Third-instar larvae trans-heterozygous for two genetic markers mwh and flr, were treated by different concentrations (1, 3, 5 ve 10 mu M) of genistein. According to our results, depending on the concentration increased, especially in small single type, the total mwh and the total clones positive results were observed. Consequently, the results of this study indicate that genistein was highly genotoxic in the SMART assay.