Akademik Veri Yönetim Sistemi
7th Drug Chemistry Conference: Design, Synthesis, Production and Standardization of Drug Active Substances, Antalya, Türkiye, 14 - 17 Mart 2019, ss.101
Deinoxanthin, a unique carotenoid synthesized by the extremophilic bacterium Deinococcus
radiodurans gives the bacterium its characteristic red color1. Deinoxanthin is one of the most important
factor for D. radiodurans resistance to UV radiation, gamma-radiation, desiccation and reactive oxygen
radicals1-2. Morever, deinoxanthin has a pro-apoptotic effect under certain conditions that is it leads
to oxidative stress by either producing ROS or inhibiting antioxidant systems in organism. Choi et al.
showed that Deinoxantin induced apoptosis in prostate and colon cancer2.
Gambogic acid is a Chinese traditional medicine that is derived from Garcinia hanburyi. Because it
inhibits cell proliferation, angiogenesis and metastasis, Gambogic acid has the potential to become an
anti-cancer drug candidate3.
In this research, we investigated the synergistic effect of Deinoxanthin (DX) and gambogic acid (GA) on
breast cancer MDA-MB-453 cells. The synergy was evaluated for total antioxidant and antiproliferative
activities. We determined the levels of total antioxidant capacity and the activity of the antioxidant
enzymes glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase in the DX
and GA-applied cells. Antiproliferative effect was determined by XTT test.