Protective effect of Prunus laurocerasus L. fruit extract against indomethacin-induced gastric ulcer in rats Prunus laurocerasus L. Meyve Ekstraktinin Siçanlarda İndometazin ile İndüklenen Gastrik Ülsere Karşi Koruyucu Etkisi

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Uslu H., Atila Uslu G.

Ataturk Universitesi Veteriner Bilimleri Dergisi, cilt.14, sa.1, ss.64-70, 2019 (Scopus, TRDizin)

Özet

© 2019 Ataturk Universitesi. All rights reserved.In the present study, it was aimed to investigate the protective effects of Prunus laurocerasus fruit extract in the indomethacine-induced gastric ulcer model, which one of the non-steroid anti-inflammatory drugs. Experimental animals were divided into four groups (Control, Prunus laurocerasus, Indomethacine and Omeprazole groups). The groups I and III was given isotonic saline, the group II was given 500 mg/kg Prunus laurocerasus extract and the group IV was given 5 mg/kg omeprazole orally. On the 11th day of the study, a single dose of 100 mg/kg indomethacine was administered orally to the II, III and IV groups. The levels of cyclooxygenase - 2 (COX-2) and C - reactive protein (CRP) increased significantly in indomethacine group (P<0.001), while significantly decreased with the application of Prunus laurocerasus (P<0.05, P<0.001 respectively) and omeprazole (P<0.01, P<0.001 respectively). It was determined that interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were increased in the indomethacin group (P<0.05). It was detected that IL-6 and TNF-α levels decreased with both Prunus laurocerasus and omeprazole administration, but these decreases were not statistically significant. In conclusion, it has been detected that Prunus laurocerasus has an omeprazole-like effect, which is one of the standard drugs in the market, when lowering CRP and COX-2 levels in gastric ulcer.