Serum leptin and ghrelin concentrations of maternal serum, arterial and venous cord blood in healthy and preeclamptic pregnant women

Aydin S., Guzel S. P., Kumru S., AYDIN S., AKIN O., Kavak E., ...Daha Fazla

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.64, sa.1, ss.51-59, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/bf03168234
  • Dergi Adı: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-59
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Preeclampsia, a common complication of pregnancy, is associated with alteration in the concentration of leptin in maternal blood. The action of leptin is antagonistic to that of ghrelin. Here, we compared the levels of leptin and ghrelin in maternal serum and in arterial and venous cord blood between healthy pregnant women and those suffering from mild and severe preeclampsia. The levels of leptin in maternal and newborn's blood were elevated in both mild and severe preeclamptic patients (p<0.05). Moreover, serum ghrelin levels were negatively correlated with blood pressure and leptin/ghrelin ratio was decreased in preeclampsia (p<0.05). We concluded that increased production of ghrelin may represent a compensatory hypotensive mechanism in preeclamptic women.