Antioxidant, antiepileptic, and anticholinergic properties of 4′,5,7-Trihydroxy-3,6-dimethoxyflavone as natural phenolic compound: a toxicology approach

Durmaz L.

Toxin Reviews, cilt.40, sa.3, ss.292-299, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/15569543.2019.1610894
  • Dergi Adı: Toxin Reviews
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.292-299
  • Anahtar Kelimeler: 4′,5,7-Trihydroxy-3,6-dimethoxyflavone, acetylcholinesterase, antioxidant activity, enzyme inhibition, metabolic enzymes
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

© 2019 Informa UK Limited, trading as Taylor & Francis Group.In this work, the antioxidant properties of 4′,5,7-trihydroxy-3,6-dimethoxyflavone using several bioanalytical assays is investigated in vitro. These methods are Cu2+-Cu+ reducing, Fe3+-Fe2+reducing, DPPH• scavenging, and ABTS•+ scavenging. The IC50 values of the 4′,5,7-trihydroxy-3,6-dimethoxyflavone for DPPH• and ABTS•+ scavenging assays were 9.36 and 3.55 μg m–1, respectively. Additionally, 4′,5,7-trihydroxy-3,6-dimethoxyflavone compound recorded best inhibitory effects against human carbonic anhydrase (hCA) I and II isoenzymes, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. 4′,5,7-Trihydroxy-3,6-dimethoxyflavone had K i value of 389.56 ± 29 nM against hCA I and 306.90 ± 41 nM toward hCA II, respectively. Also, the K i values of AChE and BChE were found as 1005.37 ± 117 nM and 814.22 ± 87 nM, respectively.