Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs

Türkeş C.

PROTEIN AND PEPTIDE LETTERS, cilt.26, sa.6, ss.392-402, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/0929866526666190226162225
  • Dergi Adı: PROTEIN AND PEPTIDE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.392-402
  • Anahtar Kelimeler: Paraoxonase, HDL, chromatography, inhibition, molecular docking, chemotherapeutic drug, protein-drug interactions, HUMAN SERUM PARAOXONASE-1, ACCURATE DOCKING, PON1, VITRO, CALCIUM, PROTEIN, PURIFICATION, ENZYMES, BINDING, HDL
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Background: Metabolic processes in living organisms are closely related to the catalytic activity of enzymes. Changes in enzyme activity cause various diseases e.g., neurological, cancer, metabolic and cardiovascular. Most of the current therapeutic drugs available in clinical utilization function as enzyme inhibitors.