Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs


Türkeş C.

PROTEIN AND PEPTIDE LETTERS, vol.26, no.6, pp.392-402, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.2174/0929866526666190226162225
  • Journal Name: PROTEIN AND PEPTIDE LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.392-402
  • Keywords: Paraoxonase, HDL, chromatography, inhibition, molecular docking, chemotherapeutic drug, protein-drug interactions, HUMAN SERUM PARAOXONASE-1, ACCURATE DOCKING, PON1, VITRO, CALCIUM, PROTEIN, PURIFICATION, ENZYMES, BINDING, HDL
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Background: Metabolic processes in living organisms are closely related to the catalytic activity of enzymes. Changes in enzyme activity cause various diseases e.g., neurological, cancer, metabolic and cardiovascular. Most of the current therapeutic drugs available in clinical utilization function as enzyme inhibitors.