Evaluation of Epithelial Cell Adhesion Molecule, Galectin‑3, and Proliferative Cell Nuclear Antigen Expression in Thyroid Papillary Carcinomas and Their Lymph Node Metastases

Daltaban F., Sayar İ., Tayfur M., Gürbüzel M., Balcı M. G.

NIGERIAN JOURNAL OF CLINICAL PRACTICE, vol.29, pp.350-355, 2026 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 29
  • Publication Date: 2026
  • Doi Number: 10.4103/njcp.njcp_346_24
  • Journal Name: NIGERIAN JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Scopus, Science Citation Index Expanded (SCI-EXPANDED), MEDLINE
  • Page Numbers: pp.350-355
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Thyroid papillary carcinoma (PTC) is the most common carcinoma

of thyroid carcinomas and endocrine carcinomas. The diagnosis of thyroid PTC is

made mainly by the presence of nuclear features such as nuclear clearing, groove,

and nuclear inclusions. Some benign lesions of the thyroid may have nuclear

features and growth patterns of papillary thyroid carcinomas, which can make the

differential diagnosis difficult. Different immunohistochemical markers have always

been needed to reduce diagnostic errors and detect malignancies in routine practice.

As in all tumor cases, studies continue to understand carcinogenesis in thyroid

carcinomas. One of the ways that can help understand this involves the use of new

and effective immunohistochemical markers.