The Molecular Mechanism Involved in the Protective Effect of Etodolac Against Ovarian Injury Induced with Ischemia/Reperfusion in Rats

AL R. A., YAPÇA Ö. E., DOĞAN H., Mammadov R., ALTUNER D., SÜLEYMAN B., ...More

LATIN AMERICAN JOURNAL OF PHARMACY, vol.34, no.3, pp.537-541, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2015
  • Journal Name: LATIN AMERICAN JOURNAL OF PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.537-541
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

This study investigated the protective effect at the molecular level of etodolac against ovarian injury induced in rats with ischemia/reperfusion (I/R). Rats were divided into four groups. The 25 mg/kg etodolac + ovarian ischemia/reperfusion (EIR 25) and 50 mg/kg etodolac+ovarian ischemia/reperfusion (EIR 50) groups were given etodolac by the oral route 1 h before administration of anesthesia. Two h of ischemia and 2 h of reperfusion were applied to ovarian tissue in all groups (except for (SG) sham operation group) 1 h after etodolac administration. The experimental results showed that etodolac at a dose of 50 mg/kg suppressed MPO (myeloperoxidase), TNF-alpha, IL-1 beta gene expression in ovarian tissue with I/R better than at a dose of 25 mg/kg. In addition, etodolac at these doses prevented a decrease in SOD gene expression in ovarian tissue subjected to I/R to a significant extent (p < 0.0001). In conclusion, etodolac can be used in the treatment of I/R-related ovarian injury.