Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease
Hypertension in Pregnancy, cilt.38, sa.1, ss.13-19, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.1080/10641955.2018.1540702
- Dergi Adı: Hypertension in Pregnancy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13-19
- Anahtar Kelimeler: oxidative stress, preeclampsia, sestrin 2
- Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır
Özet
Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = −.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.