Antiproliferative Effect of Jaceosidin in Human Gastric Carcinoma Cell Line

Dincer B., Çınar İ.

th International Medicine and Health Sciences Researches Congress, Ankara, Turkey, 25 - 26 December 2021, pp.86-87

  • Publication Type: Conference Paper / Summary Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.86-87
  • Erzincan Binali Yildirim University Affiliated: Yes


Since there is no exact effective treatment for gastric cancer, which has high morbidity and mortality rates, researchers put much scientific effort into identifying new anti-cancer agents in gastric cancer. Plant-derived substances with anti-inflammatory, antiviral, antioxidant, and anti-tumor activities, particularly those high in flavonoid content, have recently been identified as being at the forefront of discovering novel anti-cancer agents. Jaceosidin is a flavonoid derived from Artemisia species that has anti-allergic, anti-diabetic, anti-mutagenic, anti-proliferative, anti-inflammatory, and anti-oxidative properties. Jaceosidin has been discovered to exhibit anti-cancer properties and induce apoptosis in various tumor types. This research aimed to examine how anti-proliferative effects of Jaceosidin gastric cancer (AGS) cells during 24, 48, and 72 hours of treatment. AGS cell lines (ATCC, USA) were provided by The American Type Culture Collection. The MTT method was used to investigate the effect of various concentrations of Jaceosidin (0, 6.25, 12.5, 25, 50, and 100 mM) on cell viability in AGS cells. The effect of Jaceosidin on cell proliferation was determined using a migration assay. Depending on the dose and duration, Jaceosidin reduced cell proliferation. Even though Jaceosidin was only effective at doses of 100 and 50 mM for the first 24 hours, it was found to be effective at lower doses at 48 and 72 hours. According to migration assay findings, the scratched gap closure rate was significantly lower (p<0.001) than the Control, especially at high dosages (100, 50, 25 mM). Consequently, the study has been shown that Jaceosidin inhibits proliferation in AGS cells and could be used as an anti-cancer agent in the future.