Serum peroxisome proliferator-activated receptor-gamma levels in acute phase of male patients with schizophrenia and their relationship with metabolic parameters

Kalelioglu T., Durak N., Karamustafalioglu N., Genc A., Akkus M., Tasdemir A., ...Daha Fazla

Psychiatry and Clinical Psychopharmacology, cilt.27, sa.1, ss.30-34, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/24750573.2017.1293244
  • Dergi Adı: Psychiatry and Clinical Psychopharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.30-34
  • Anahtar Kelimeler: Inflammation, Metabolic syndrome, PPAR-gamma, Schizophrenia
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

© 2017 The Author(s).Objective: Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor family providing the modulation of the genes having a role in gluco-lipid metabolism and inflammation. Here, we aimed to compare serum PPARγ levels between medication-free schizophrenia patients and healthy controls. Methods: Forty-five inpatients with schizophrenia and 39 healthy controls were included in the study. Serum PPARγ levels and metabolic syndrome (MetS) parameters of the patients and controls were compared. Results: There were no statistically significant differences between the patients (1.42 ± 0.64 ng/ ml) and the control group (1.59 ± 1.10 ng/ml) in terms of serum PPARγ levels. No statistically significant correlations were determined between the MetS parameters and PPARγ levels. Conclusions: Our findings showed that PPARγ, which we predicted to have a role in metabolic disorders and inflammatory process in schizophrenia, did not seem to have a role in the acute exacerbation of schizophrenia.