Serum peroxisome proliferator-activated receptor-gamma levels in acute phase of male patients with schizophrenia and their relationship with metabolic parameters
Psychiatry and Clinical Psychopharmacology, vol.27, no.1, pp.30-34, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 1
- Publication Date: 2017
- Doi Number: 10.1080/24750573.2017.1293244
- Journal Name: Psychiatry and Clinical Psychopharmacology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.30-34
- Keywords: Inflammation, Metabolic syndrome, PPAR-gamma, Schizophrenia
- Erzincan Binali Yildirim University Affiliated: No
Abstract
© 2017 The Author(s).Objective: Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor family providing the modulation of the genes having a role in gluco-lipid metabolism and inflammation. Here, we aimed to compare serum PPARγ levels between medication-free schizophrenia patients and healthy controls. Methods: Forty-five inpatients with schizophrenia and 39 healthy controls were included in the study. Serum PPARγ levels and metabolic syndrome (MetS) parameters of the patients and controls were compared. Results: There were no statistically significant differences between the patients (1.42 ± 0.64 ng/ ml) and the control group (1.59 ± 1.10 ng/ml) in terms of serum PPARγ levels. No statistically significant correlations were determined between the MetS parameters and PPARγ levels. Conclusions: Our findings showed that PPARγ, which we predicted to have a role in metabolic disorders and inflammatory process in schizophrenia, did not seem to have a role in the acute exacerbation of schizophrenia.