Synthesis, Structural Characterization and Investigation of Antiproliferative Activities of New Drug Candidate Molecules

Merkit K., Tuna Yıldırım S., Kağan Yeniçeri E. K., Altay A.

7th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem), Ankara, Türkiye, 2 - 04 Ekim 2024, ss.75

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.75
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Cancer is one of the deadliest diseases that affects millions of people worldwide, and today there are many different treatment methods depending on the type and stage of cancer [1]. Chemotherapy is one of the methods used in the treatment process of cancer patients, and it is known that these drugs have side effects such as hair loss, diarrhea and loss of appetite during the treatment process. Considering the side effects and toxicity of existing drugs, it is important to conduct studies on the discovery of new drugs with minimum side effects and maximum therapeutic potential. So examination of the chemical basis of the pharmacological properties and mechanism of action of inorganic and organometallic compounds is great importance for drug research [2]. Research on metal-based chemotherapeutics has gained momentum after the groundbreaking discovery of cisplatin and related complexes as potential anticancer agents. Schiff bases, which have many biological and pharmacological activities, are widely used in this field due to their anticancer activities. Schiff base transition metal complexes with anticancer activity are promising molecules for cancer chemotherapy, and therefore their synthesis and activity studies have recently gained great importance in the field of medicine and pharmacy [3]. In this study, an imine compound was synthesized and then this compound was used as a ligand for the preparation of metal complexes. Elemental analysis and some spectroscopic techniques such as FT-IR, 1HNMR, 13C-NMR, XRD, SEM and UV-Vis were used at structural characterization [4]. The antiproliferative activities of these compounds were investigated in breast cancer MCF-7 and MDA-MB-453 cell lines [5]. It was found that the complexes exhibited greater activity compared to the ligand in both cell lines. The Ni complex also had a greater effect with a lower IC50 value compared to positive carboplatin in both cancer cell lines.