Atıf İçin Kopyala
Gulsah Aynaoglu Yildiz G., Erkan Yapca O., Dinc K., Gursul C., Gundogdu B., Aktas M., ...Daha Fazla
REVISTA DE INVESTIGACION CLINICA, cilt.64, sa.4, ss.513-523, 2023 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
64
Sayı:
4
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Basım Tarihi:
2023
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Doi Numarası:
10.54817/ic.v64n4a08
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Dergi Adı:
REVISTA DE INVESTIGACION CLINICA
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals, DIALNET
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Sayfa Sayıları:
ss.513-523
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Erzincan Binali Yıldırım Üniversitesi Adresli:
Hayır
Özet
Abstract. Many types of stress, including psychological stress, nega-tively affect reproductive health. This study aimed to investigate the ef-fects of sertraline (a selective serotonin reuptake inhibitor), cerebrolysin (neuroprotective/neurotrophic), and a combination of both against stress-induced ovarian damage, infertility and pregnancy delay in female rats. The rats were divided into five groups (n=14/each group) as healthy (HG), stress control (StC), stress+sertraline (SS), stress+cerebrolysin (SC), and stress+sertraline+cerebrolysin (SSC). To induce stress, animals (except the HG) were kept in a supine position with their forelimbs and hindlimbs (FIM) tied for one hour. Then, sertraline (20mg/kg) was given orally to the SS. Cerebrolysin (2.5ml/kg) was injected into the SC subcutaneously. Sertraline+cerebrolysin was administered to SSC with the same methods and doses. FIM and drug administration continued for 30 days. Six rats from each group were euthanized with high-dose anesthesia, right and left ovarian tissues were removed, and tissues were examined biochemically and histopathologi-cally. The remaining rats were taken for breeding. Exposure to stress in rats caused an increase in malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL -1β), and interleukin-6 (IL -6) levels and a decrease in total glutathione (tGSH). Stress was related to histopathological damage, infertility, and delayed birth. The sertraline and cerebrolysin combination was the most effective in preventing these changes, with sertraline and cerebroly-sin alone in second and third places, respectively. Regarding efficacy, selective serotonin reuptake inhibitors (SSRIs) and related drugs may be beneficial in treating stress-related ovarian damage, infertility, and delay in pregnancy.