Akademik Veri Yönetim Sistemi
Fresenius Environmental Bulletin, cilt.28, sa.8, ss.6268-6274, 2019 (SCI-Expanded)
© 2019 Parlar Scientific Publications. All rights reserved.Although diabetes mellitus affects many sys tems, it has very negative effects on the cardiovascu lar system. However, its effects on the cardiovascu lar system are often underestimated, and nephropa thy, neuropathy and retinopathy are emphasised in particular. Therefore, the aim of this study was to de termine the antihyperglycemic and antihyper-lipidemic effects of Ferula orientalis (FO) extract and its effects on cardiovascular dysfunction. Over all, 40 rats were divided into 5 groups with 8 rats in each group. The groups were NC, FO, DC, D+FO and D+I. FO and insulin were administered for 21 days in an experimental type 1 diabetic rat model in-duced with streptozotocin (STZ). On the 3rd day of STZ administration, fasting blood glucose (FBG) level was significantly increased in all diabetic groups. Starting on the 10th day, a significant de-crease was observed in the FBG levels of the D+FO and D+I groups. FO extract increased plasma insulin levels in diabetes mellitus, decreased HbAlc levels and was also effective in preventing rapid weight loss seen in type 1 diabetes mellitus. Furthermore, FO was effective in decreasing the elevated TG and LDL cholesterol levels in diabetes mellitus. In the DC group, the levels of NO and COX-2 in heart and thoracic aorta tissues were significantly increased Conversely, a significant decrease was observed in the COX-2 and NO levels in the thoracic aorta tissue and in NO levels in the heart tissue in the D+FO group. In conclusion, it was found that FO had im portant antihyperglycemic and antihyperlipidemic effects and was also effective in suppressing dys function in heart and thoracic aorta tissue caused by diabetes mellitus.