Akademik Veri Yönetim Sistemi
ACTA FARMACEUTICA BONAERENSE, cilt.40, sa.11, ss.2821-2828, 2021 (ESCI)
Infertility is a tragic option for reproductive-aged women. About 20 % of lost ability to conceive
are caused by unexplained etiology. Some of these cases are linked with psychological stress. It can cause
depression and anxiety, and the latter can cause infertility. The therapy with sedative, antidepressant, anxiolytic and antioxidant effects may be beneficial in preventing infertility caused by psychological disorders
and maintaining normal intrauterine physical development of the fetus. The aim of our study is to investigate the protective effect of Valeriana plant root extract against stress-induced reproductive disorders. The
protective effect of Valeriana plant root extract against infertility and delayed maternity was investigated
in a stress model induced by the forced immobilization method in albino Wistar female rats and compared
with ascorbic acid. Valeriana officinalis plant root extract was effective against psychological stress-related
infertility and delayed maternity, ascorbic acid was found to be ineffective. This information suggests that
psychological stress-related ovarian damage, infertility, delayed maternity, and great obstetric syndromes
are based on the role of psychological disorders such as anxiety and depression rather than oxidative stress.
Our experimental results indicate that Valeriana officinalis plant root extract can be useful in the treatment
of stress-related ovarian damage and reproductive disorders