The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

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KUYRUKLUYILDIZ U., KÜPELİ İ., bedir Z., ÖZMEN O., ONK D., SÜLEYMAN B., ...More

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, vol.44, no.6, pp.287-294, 2016 (ESCI, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 44 Issue: 6
• Publication Date: 2016
• Doi Number: 10.5152/tjar.2016.02212
• Journal Name: TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.287-294
• Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Objective: Paclitaxel is used in the treatment of cancer, and it may cause interleukin-1 beta (IL-1 beta)-related peripheral neuropathic pain. While our primary aim was to investigate the analgesic efficacy of an IL-1 beta antagonist, a secondary outcome was to assess whether a correlation exists between analgesic effects and antioxidant activity.