Effect of Molnupiravir on Ichemia/Reperfusion Damage in Rat Liver, an Experimental Study

TAŞ H. G., TAŞ N. G., KUYRUKLUYILDIZ U., ZIRH S., KURT N.

Latin American Journal of Pharmacy, cilt.42, sa.11, ss.2382-2389, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 11
  • Basım Tarihi: 2023
  • Dergi Adı: Latin American Journal of Pharmacy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.2382-2389
  • Anahtar Kelimeler: ischemia/reperfusion, liver tissue, molnupiravir, oxidative stress
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

The purpose of this study is to see how molnupiravir affects I/R-induced damage of liver in rats. Three rat groups were used in the study: SG (n = 6), LIR (n = 6), and MIR (n = 6).Molnupiravir 40 mg/kg was given to MIR rats.A laparotomy was performed, as well as hepatic ischemia (1 hour) and reperfusion (6 hours). IL-1β, tGSH, NF-κB, MDA, TNF-α, and histopathology were all examined in liver tissue. ALT and AST levels were measured in blood samples. The LIR and MIR groups had higher NF-κB, MDA, TNF-α, IL-1β, ALT, and AST levels than the SG group.The greatest tGSH levels were seen in SG. The MIR group received the most damage, according to histopathological examinations. Molnupiravir, which is used to treat COVID-19 without causing liver damage, aggravates ischemia/reperfusion injury in stressed liver tissue. Molnupiravir should be used with caution in procedures such as liver transplantation or resection to avoid liver injury.