Akademik Veri Yönetim Sistemi
V. International Van Scientific Research Congress, Van, Türkiye, 8 - 10 Ağustos 2025, ss.312-313, (Özet Bildiri)
In recent years, there has been a significant increase in studies focusing on natural phenolic compounds and flavonoids. This increasing attention highlights the potential of medicinal plants for pharmaceutical and therapeutic applications. Medicinal plants are important natural sources of phytochemicals—structurally diverse secondary metabolites synthesized by plants— which often demonstrate significant biological activities. These compounds have attracted increasing attention in pharmaceutical and medical sciences due to their potential applications in the prevention and treatment of various diseases, as well as their support of physiological functions. The composition and concentration of plant secondary metabolites are determined by genetic factors, as well as by environmental conditions such as soil composition, climate, and geographical origin. Additionally, different morphological parts of medicinal plants (such as flowers, leaves, stems, roots, and rhizomes) may differ in both the type and concentration of phenolic and flavonoid compounds. While many medicinal plant species have been comprehensively investigated, the phytochemical profiles of numerous local and endemic species are still understudied. In this study, Hedysarum candidissimum, a species naturally distributed in the flora of Turkey and traditionally used in folk medicine, was investigated. Plant samples were collected from the villages of Acemoğlu, Dumanlı, and Yahşiler in the Kemah district of Erzincan province, and divided into three organs: leaves, stems, and roots. Methanolic extracts were prepared from each organ, and their total phenolic and flavonoid contents, as well as antioxidant activities, were evaluated using DPPH radical scavenging and FRAP assays. The highest biological activity was observed in the leaf samples from the Dumanlı location, with total phenolic content measured at 136.86 mg GAE/g, total flavonoid content at 72.80 mg QE/g, FRAP value at 180.52 μg TE/g, and DPPH IC50 at 7.83 μg/mL. Among the stem samples, the highest values were observed in the Acemoğlu population, while the root samples from Yahşiler demonstrated the highest levels within their group. The findings indicate that H. candidissimum shows significant phytochemical potential, attributed to its high levels of phenolic compounds and strong antioxidant activity. In addition, the observed variations in phytochemical content and biological activity across different locations and plant organs indicate that both environmental and morphological factors should be considered in the pharmacological evaluation of this species. These results provide a valuable reference point for future pharmacological and biotechnological research.