Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors

Mirzaoglu M., Yavuzkir S., Mirzaoglu C., Yurt N., Dagli A. F., Ozcan Yildirim S., ...Daha Fazla

Biotechnic and Histochemistry, cilt.98, sa.2, ss.140-146, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10520295.2022.2135763
  • Dergi Adı: Biotechnic and Histochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.140-146
  • Anahtar Kelimeler: Asprosin, metrnl, subfatin, meteorin-like protein, serous ovarian cancer
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

© 2022 The Biological Stain Commission.Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.