Y Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3-picoline on paraoxanase-I

Dilek E., Çağlar S., Cardak S., Karakoc B., Çağlar B., Şahin O.

ARCHIV DER PHARMAZIE, cilt.352, sa.6, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 352 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/ardp.201900007
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: copper(II) complex, crystal structure, enzyme inhibition, niflumic acid, paraoxonase 1, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, COPPER(II) COMPLEXES, CRYSTAL-STRUCTURES, THERMAL-PROPERTIES, CATECHOL OXIDASE, MEFENAMIC-ACID, DNA, SPECTROSCOPY, DICLOFENAC, GHRELIN
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Niflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti-inflammatory drug niflumic acid, 3-picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu2Cl2(nif)(2)(3-pic)(4)]. The crystal structure of [Cu2Cl2(nif)(2)(3-pic)(4)] was determined by X-ray crystallography. The complex crystallizes in the triclinic space group P-1 and each Cu(II) center displayed six-coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro-bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.